Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

Comparison Testing of Competitive Portable Jet Nebulizers

A comparison of commercial jet nebulizers.

Seventeen commercially available jet nebulizers from 15 commercial sources were studied (Acorn-I, Acorn-II, AquaTower, AVA-NEB, Cirrhus, Dart, DeVilbiss 646, Downdraft, Fan Jet, MB-5, Misty Neb, PARI LC JET, PARI-JET, Salter 8900, Sidestream, Updraft-II, Whisper Jet). All nebulizers were filled with 2 ml of saline solution plus 0.5 ml of albuterol and powered with the same source (DeVilbiss Pul...

Nebulizers: principles and performance.

Nebulizers have been used clinically for many years. Despite the increasing use of metered-dose inhalers and dry powder inhalers, it is likely that nebulizers will continue to be used in selected patients. A number of factors affect nebulizer performance, and these should be appreciated by clinicians who use these devices. Several new designs have recently become available that improve the perf...

Output characteristics of DeVilbiss No. 40 hand-held jet nebulizers.

DeVilbiss No. 40 hand-held nebulizers are widely used for quantifying airway responsiveness in large populations using pharmacological agents. We examined the aerosol characteristics of five nebulizers. Within each device, the aerosol output and droplet size were reasonably stable over a wide range of bulb pressures, although there were considerable differences in output characteristics between...

Overcoming jet lag: optimizing aerosol delivery with and without jet nebulizers.

Early studies have shown that only a small fraction of the nominal nebulizer dose (1–12%) is available for delivery to the lungs in intubated children and adults.1-3 Since then, the characterization of forces governing aerosol delivery in ventilated patients has led to improvements in techniques, and the development of newer aerosol generators with the ability to deliver as much drug to ventila...